Evaluation of the Citalopram levels on QTc Interval in Rats using with Radio-telemetry

Long QT syndrome is an arrhythmogenic disease characterized by prolonged interval. Citalopram (CIT) was reported to prolong interval dose-dependently. Omeprazole (OMP), inhibits CIT metabolizing enzyme CYP2C19, thereby increases serum concentrations which may increase the risk of prolongation. These are commonly co-prescribed and recent studies have raised safety concerns about. We aimed investigate dose dependent effects citalopram alone in combination with OMP. Forty male, Sprague Dawley rats were divided into 5 groups (n=8). (10 mg/kg or 30 mg/kg) given for 2 weeks OMP (100 starting from 2nd week. ECG recordings blood samples collected. significantly increased all compared control. The plasma level CIT30 group higher than CIT10 (p<0.01) CIT10+OMP that (p<0.01). In treatment groups, correlated positively (r=0.844, r2=0.713). It determined caused prolongation interval, addition more, these concentration. Therefore, it would be appropriate routinely measure levels ECG, particularly patients additional factors